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. 2020 Dec 22;12(12):e12222. doi: 10.7759/cureus.12222

Table 2. Synopsis of metabolic regulation from past studies.

ASD: Autism spectrum disorder; PGI-R: Patient Global Impression-Revised

Author Year Sample Size (N) Conclusion
Żarnowska et al. [7] 2018 35 and a single case study Concluded that the ketone diet shows tremendous improvement in behavior, eating habits, and tantrums
Nadon et al. [13] 2010 and 2011 95 cases, compared autistic children with non-autistic siblings from the same family. Identified sensory problems concerning food and eating habits. Concluded that sensory habits are completely different and can be haywire in these children.
Napoli et al. [14] 2014 N/A A ketogenic diet reduces mitochondrial gene expression helping improve symptoms.
Cheng et al. [15] 2017 N/A A ketogenic diet reduces mitochondrial gene expression, and hence there is a significant improvement in behavior, hunger, and other major autistic symptoms.
Adams et al. [16] 2011 141 Vitamins and minerals have good effects on ASD and autism, improved PGI-R subscales, tantrums, receptive language.
Cruchet et al. [21] 2016 N/A Nonceliac gluten sensitivity diet and vegetarian diet improve the behavioral outcome.
Zuckerman et al. [24] 2015 376 Complementary and alternative medicines worked better for most children. Reduced medication and melatonin worked great with the least side effects and improvement in sleep.
Jones et al. [27] 2017 35 Increased socialization, motor skills, and physical activity regulates hunger and changes social-emotional and developmental functioning.