Table 2. Synopsis of metabolic regulation from past studies.
ASD: Autism spectrum disorder; PGI-R: Patient Global Impression-Revised
Author | Year | Sample Size (N) | Conclusion |
Żarnowska et al. [7] | 2018 | 35 and a single case study | Concluded that the ketone diet shows tremendous improvement in behavior, eating habits, and tantrums |
Nadon et al. [13] | 2010 and 2011 | 95 cases, compared autistic children with non-autistic siblings from the same family. | Identified sensory problems concerning food and eating habits. Concluded that sensory habits are completely different and can be haywire in these children. |
Napoli et al. [14] | 2014 | N/A | A ketogenic diet reduces mitochondrial gene expression helping improve symptoms. |
Cheng et al. [15] | 2017 | N/A | A ketogenic diet reduces mitochondrial gene expression, and hence there is a significant improvement in behavior, hunger, and other major autistic symptoms. |
Adams et al. [16] | 2011 | 141 | Vitamins and minerals have good effects on ASD and autism, improved PGI-R subscales, tantrums, receptive language. |
Cruchet et al. [21] | 2016 | N/A | Nonceliac gluten sensitivity diet and vegetarian diet improve the behavioral outcome. |
Zuckerman et al. [24] | 2015 | 376 | Complementary and alternative medicines worked better for most children. Reduced medication and melatonin worked great with the least side effects and improvement in sleep. |
Jones et al. [27] | 2017 | 35 | Increased socialization, motor skills, and physical activity regulates hunger and changes social-emotional and developmental functioning. |