Table 2.
Cytotoxicity comparison of trichophycins, trichotoxins, and tricholactone against neuro-2a cells.
| Compound Name | Structure | EC50 [mean ± SE (μM)] |
|---|---|---|
| Trichophycin A |  |
6.5 ± 1.47 |
| Trichophycin G (2) |  |
8.4 ± 3.0 |
| Trichophycin H (3) |  |
12 ± 1 |
| Isotrichophycin C (1) |  |
13 ± 1 |
| Trichophycin F |  |
14 ± 28 |
| Trichophycin B |  |
15 ± 28 |
| Trichophycin C |  |
24 ± 48 |
| Trichophycin D |  |
40 ± 48 |
| Trichophycin E |  |
>1008 |
| Trichotoxin A |  |
>5010 |
| Trichotoxin B |  |
>5010 |
| Trichophycin A tri Ac |  |
>100 |
| Isotrichophycin C di Ac |  |
>100 |
| Tricholactone |  |
>100 |