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. 2020 Dec;9(6):2411–2427. doi: 10.21037/tlcr-20-1250

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2020 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Sirt1 promotes the proliferation and migration of lung adenocarcinoma cells. (A) Knockdown efficiency of Sirt1 in H1975 and SPC-A1 cells, as determined by western blot. (B) Knockdown of Sirt1 suppressed the proliferation in H1975 and SPC-A1 cells, as detected with CCK-8 assays. (C) The effect of Sirt1 knockdown on the cell cycle in H1975 and SPC-A1 cells, as analyzed by ﬂow cytometry. (D,E) The expression of EMT-related proteins in H1975 and SPC-A1 cells, as determined by Western blot after Sirt1 knockdown. (F) Knockdown of Sirt1 suppressed the migration ability of H1975 and SPC-A1 cells, as determined by Transwell assays (200×). *, P<0.05; **, P<0.01. Sirt1, silent information regulator-1; CCK-8, Cell Counting Kit-8.