Table 3.
GO enrichment analysis of the potential targets.
| Term | Genes | |
|---|---|---|
| Biological process | Metabolism | GM2A; CBR1; SULT2A1; AKR1B1; LSS; HSD17B1; HSD11B1; NR1H4; AKR1C2; AKR1C3; EPHX2; AKR1C1; STS; CYP2C9; PLA2G2A; BCHE; GSTM1; GSTM2; HPGDS; HMGCR; PLA2G10; PNMT |
| Energy pathways | GM2A; CBR1; SULT2A1; AKR1B1; LSS; HSD17B1; AKR1C3; EPHX2; AKR1C1; STS; CYP2C9; PLA2G2A; BCHE; GSTM1; GSTM2; HPGDS; HMGCR; PLA2G10; PNMT | |
| Bone remodeling | RORA | |
| Transport | FABP6; APOA2; FABP7; FABP3; ALB; AKR1C2; GC; PCTP | |
| Xenobiotic metabolism | GSTM1 | |
| Transcription | PPARD | |
| Regulation of gene expression, epigenetic | VDR | |
| Cell communication | FABP4; PIK3R1; NR1H4; NR1H3; NR1H2; MAPKAPK2; RXRB; RXRA | |
| Signal transduction | FABP4; PIK3R1; NR1H4; NR1H3; NR1H2; MAPKAPK2; RXRB; RXRA | |
| Protein metabolism | LTA4H; DPEP1 | |
|
| ||
| Molecular function | Ligand-dependent nuclear receptor activity | PPARA; NR1H4; NR1H3; NR1H2; RXRB; RXRA |
| Transporter activity | FABP6; APOA2; FABP7; GM2A; FABP3; ALB; AKR1C2; GC; PCTP | |
| Catalytic activity | LSS; HSD17B1; HSD11B1; AKR1C3; AKR1C1; STS; CYP2C9; HMGCR | |
| Glutathione transferase activity | GSTM1; GSTM2 | |
| Phospholipase activity | PLA2G2A; PLA2G10 | |
| Oxidoreductase activity | CBR1; AKR1B1; AKR1C2 | |
| Hydrolase activity | EPHX2; BCHE; LTA4H | |
| Transcription factor activity | PPARD; VDR; PPARG | |
| Protein serine/threonine kinase activity | MAPKAPK2 | |
| DNA binding | RORA | |
|
| ||
| Cellular component | Extracellular region | APOA2; ALB; PLA2G2A; BCHE; GC; PLA2G10 |
| Cytoplasm | FABP6; APOA2; FABP7; FABP4; FABP3; PPARA; CBR1; SULT2A1; AKR1B1; PIK3R1; HSD17B1; ALB; AKR1C3; EPHX2; AKR1C1; NR1H2; PLA2G2A; MAPKAPK2; GC; GSTM1; GSTM2; VDR; HPGDS; LTA4H; PCTP; PPARG | |
| Cytosol | SULT2A1; AKR1B1; PIK3R1; AKR1C2; EPHX2; AKR1C1; MAPKAPK2; PCTP; PNMT | |
| Exosomes | APOA2; GM2A; FABP3; CBR1; AKR1B1; ALB; EPHX2; GSTM2; LTA4H; DPEP1; PPARG | |
| Extracellular | APOA2; GM2A; FABP3; AKR1B1; ALB; PLA2G2A; BCHE; GC; HMGCR; PLA2G10 | |
| Endoplasmic reticulum | LSS; HSD11B1; STS; CYP2C9; PLA2G2A; HMGCR; DPEP1 | |
| Lysosome | APOA2; GM2A; CBR1; AKR1B1; LSS; HSD17B1; ALB; STS | |
| Extracellular space | AKR1B1; ALB; PLA2G2A | |
| Nucleus | ESRRA; PPARA; PPARD; PIK3R1; ALB; NR1H4; NR1H3; AKR1C3; NR1H2; MAPKAPK2; RXRB; RXRA; VDR; LTA4H; PPARG; RORA | |
| Plasma membrane | PIK3R1; STS; GC | |