Table 2.
Results for intestinal permeability measured by a lactulose and mannitol intestinal absorption assay, and for faecal calprotectin and zonulin analysis.
| pSS (n = 20)a | MS (n = 18) | HC (n = 10) | p values | |
|---|---|---|---|---|
| pSS-MS: >0.05 | ||||
| Lactulose/mannitol ratio | 0.023 (0.018; 0.035) | 0.031 (0.024; 0.040) | 0.002 (0.001; 0.012) | pSS-HC: <0.001 |
| MS-HC: <0.001 | ||||
| pSS-MS: 0.005 | ||||
| Faecal calprotectin (μg/g) | 111 (25.5; 195) | 38.1 (24.3; 61.8) | 38.9 (24.1; 75.7) | pSS-HC: 0.020 |
| MS-HC: >0.05 | ||||
| pSS-MS: >0.05 | ||||
| Faecal zonulin (ng/mL) | 103 (73.5; 143) | 134 (82.5; 194) | 105 (81.6; 132) | pSS-HC: >0.05 |
| MS-HC: >0.05 |
HC, healthy controls; MS, multiple sclerosis; pSS, primary Sjögren’s syndrome.
Values are given as median (interquartile range).
a
For one pSS patient lactulose/mannitol ratio could not be determined due to loss of the urine during storage.