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. 2021 Jan 6;11:588679. doi: 10.3389/fphys.2020.588679

FIGURE 8.

FIGURE 8

Computer simulation of action potentials of a human ventricular myocyte coupled to 10 (left panels) or 20 CPCs (right panels) overexpressing Hcn2 alone (green line), or Hcn2 + SkM1 (red line). The blue line shows the action potentials of the myocyte coupled to 10 (left) or 20 (right) empty CPCs. (A) Last two action potentials of a train of 100, induced by a 1 ms, ≈50% suprathreshold stimulus. Formation of stable pacemaker function after ending the train of stimuli is found only with the larger number of CPCs and only in the Hcn2 + SkM1 group and not in the simulation with Hcn2 alone. (B) Corresponding membrane potential of each of the CPCs. (C) Total junctional current flowing from the myocyte to the CPCs. Positive junctional current is outward for the myocyte, but inward for the CMPCs, and vice versa. (D,E) Membrane ion currents IK1 and INa of the myocyte. (F,G) Membrane ion currents IHcn2 and ISkM1 of each of the CPCs.