Skip to main content
. 2020 Nov 23;50(1):159–176. doi: 10.1007/s10964-020-01353-4

Table 1.

Summary of correlations among the different polygenic risk scores and all study variables (N = 327)

Variable 1 2 3 4 5 6 7
1. Depressive symptoms T1 –
2. Depressive symptoms T2 0.58*** –
3. Depressive symptoms T3 0.56*** 0.66*** –
4. Depressive symptoms T4 0.55*** 0.64*** 0.71*** –
5. Depressive symptoms T5 0.51*** 0.57*** 0.64*** 0.79*** –
6. Depressive symptoms T6 0.51*** 0.53*** 0.61*** 0.70*** 0.75*** –
7. Parental criticisma 0.37*** 0.39*** 0.38*** 0.43*** 0.42*** 0.37*** –
8. PRS MDD 5 × 10−8b 0.15** 0.13* 0.16** 0.17** 0.13* 0.11* 0.05
9. PRS MDD 5 × 10−7 0.10 0.18*** 0.18** 0.19*** 0.19*** 0.14* 0.09
10. PRS MDD 5 × 10−6 0.07 0.17** 0.16** 0.17** 0.17** 0.12* 0.06
11. PRS MDD 5 × 10−5 0.11* 0.12* 0.15** 0.18*** 0.20*** 0.14* 0.07
12. PRS MDD 5 × 10−4 0.12* 0.11* 0.13* 0.16** 0.16** 0.14** 0.06
13. PRS MDD 5 × 10−3 0.10 0.15** 0.15** 0.13* 0.11* 0.13* 0.08
14. PRS MDD 0.01 0.10 0.14** 0.15** 0.13* 0.13* 0.16** 0.09
15. PRS MDD 0.05 0.13* 0.18** 0.19*** 0.16** 0.15** 0.17** 0.15**
16. PRS MDD 0.10 0.13* 0.18** 0.18** 0.15** 0.14* 0.17** 0.14**
17. PRS MDD 0.20 0.14* 0.19*** 0.18** 0.17** 0.16** 0.18** 0.18**
18. PRS MDD 0.30 0.14* 0.18*** 0.18** 0.16** 0.15** 0.18** 0.19***
19. PRS MDD 0.40 0.15** 0.19*** 0.19*** 0.17** 0.16** 0.18** 0.21***
20. PRS MDD 0.50 0.15** 0.19*** 0.19*** 0.17** 0.16** 0.18** 0.20***

PRS MDD […] = polygenic risk score for major depression, calculated based on the mentioned p-value threshold

aAdolescent- and mother-reports of parental criticism across 6 successive years were combined into a single multi-informant longitudinal average, with higher levels representing higher levels of parental criticism

bThe PRS MDD 5 × 10−8 score was based on the meta-analysis by Hyde et al. (2016) and corrected for adolescent age, sex, and population stratification. The other 12 polygenic risk scores for major depression with different p-value thresholds were based on the 23andMe summary statistics and also corrected for adolescent age, sex, and population stratification

*p < 0.05; **p < 0.01; ***p < 0.001