Table 3.

Summary of standardized coefficients of polygenic risk for MDD predicting adolescent depressive symptom development, controlling for sex (N = 327)

Model	Intercepta	Linear slope	Quadratic slope
PRS MDD 5 × 10−8b	β = 0.17, p = 0.019	β = 0.08, p = 0.412	β = −0.10, p = 0.324
PRS MDD 5 × 10−7	β = 0.13, p = 0.038	β = 0.19, p = 0.022	β = −0.18, p = 0.041
PRS MDD 5 × 10−6	β = 0.09, p = 0.159	β = 0.21, p = 0.018	β = −0.20, p = 0.034
PRS MDD 5 × 10−5	β = 0.12, p = 0.083	β = 0.15, p = 0.127	β = −0.12, p = 0.236
PRS MDD 5 × 10−4	β = 0.13, p = 0.043	β = 0.08, p = 0.435	β = −0.05, p = 0.631
PRS MDD 5 × 10−3	β = 0.14, p = 0.017	β = 0.08, p = 0.435	β = −0.07, p = 0.509
PRS MDD 0.01	β = 0.16, p = 0.011	β = 0.04, p = 0.696	β = −0.01, p = 0.946
PRS MDD 0.05	β = 0.19, p = 0.002	β = 0.07, p = 0.542	β = −0.05, p = 0.656
PRS MDD 0.10	β = 0.19, p = 0.003	β = 0.04, p = 0.711	β = −0.02, p = 0.842
PRS MDD 0.20	β = 0.20, p = 0.002	β = 0.05, p = 0.632	β = −0.04, p = 0.744
PRS MDD 0.30	β = 0.20, p = 0.001	β = 0.04, p = 0.701	β = −0.03, p = 0.812
PRS MDD 0.40	β = 0.21, p = 0.001	β = 0.06, p = 0.595	β = −0.05, p = 0.685
PRS MDD 0.50	β = 0.21, p = 0.001	β = 0.05, p = 0.654	β = −0.04, p = 0.729

PRS MDD […] = polygenic risk score for major depression, calculated based on the mentioned p-value threshold. Significant main effects (p < 0.05) are in bold

^aThe average age of participants at the intercept was 13.00 years old (SD = 0.44)

^bThe PRS MDD 5 × 10⁻⁸ score was based on the meta-analysis by Hyde et al. (2016) and corrected for adolescent age, sex, and population stratification. The other 12 polygenic risk scores for major depression with different p-value thresholds were based on the 23andMe summary statistics and also corrected for adolescent age, sex, and population stratification