Table 4.

Summary of standardized coefficients of polygenic risk for MDD × sex interactions predicting adolescent depressive symptom development (N = 327)

Model	Intercepta	Linear slope	Quadratic slope
PRS MDD 5 × 10−8b	β = 0.15, p = 0.123	β = 0.21, p = 0.081	β = −0.24, p = 0.052
PRS MDD 5 × 10−7	β = 0.20, p = 0.011	β = 0.15, p = 0.181	β = −0.14, p = 0.264
PRS MDD 5 × 10−6	β = 0.24, p = 0.004	β = 0.11, p = 0.338	β = −0.13, p = 0.311
PRS MDD 5 × 10−5	β = 0.24, p = 0.007	β = 0.26, p = 0.055	β = −0.24, p = 0.089
PRS MDD 5 × 10−4	β = 0.12, p = 0.185	β = 0.35, p = 0.011	β = −0.34, p = 0.015
PRS MDD 5 × 10−3	β = 0.07, p = 0.390	β = 0.34, p = 0.008	β = −0.35, p = 0.010
PRS MDD 0.01	β = 0.09, p = 0.294	β = 0.34, p = 0.007	β = −0.35, p = 0.007
PRS MDD 0.05	β = 0.15, p = 0.084	β = 0.25, p = 0.087	β = −0.28, p = 0.066
PRS MDD 0.10	β = 0.14, p = 0.107	β = 0.22, p = 0.135	β = −0.25, p = 0.104
PRS MDD 0.20	β = 0.15, p = 0.098	β = 0.23, p = 0.119	β = −0.27, p = 0.077
PRS MDD 0.30	β = 0.17, p = 0.053	β = 0.18, p = 0.224	β = −0.23, p = 0.148
PRS MDD 0.40	β = 0.17, p = 0.040	β = 0.19, p = 0.194	β = −0.23, p = 0.141
PRS MDD 0.50	β = 0.16, p = 0.053	β = 0.20, p = 0.176	β = −0.23, p = 0.128

PRS MDD […] = polygenic risk score for major depression, calculated based on the mentioned p-value threshold. Significant interactions (p < 0.05) are in bold

^aThe average age of participants at the intercept was 13.00 years old (SD = 0.44)

^bThe PRS MDD 5 × 10⁻⁸ score was based on the meta-analysis by Hyde et al. (2016) and corrected for adolescent age, sex, and population stratification. The other 12 polygenic risk scores for major depression with different p-value thresholds were based on the 23andMe summary statistics and also corrected for adolescent age, sex, and population stratification