Table 3.
Nerve Ultrasound CSA in ATTRv patients with polyneuropathy (PN) and pre-symptomatic carriers
| Site | Mean SD (mm2) | p values | |
|---|---|---|---|
| ATTRv-PN (N = 34) | ATTRv carriers (N = 28) | ||
| Median nerve at wrist | 9.7 (2.4) n = 67 | 8.8 (2.7) n = 55 | 0.033 |
| Median nerve at forearm | 6.7 (1.9) n = 67 | 5.8 (1.5) n = 56 | 0.008 |
| Median nerve at elbow | 10.2 (3.0) n = 67 | 8.2 (1.9) n = 56 | 0.000* |
| Median nerve at arm | 10.4 (3.3) n = 67 | 8.3 (2.1) n = 56 | 0.000* |
| Median nerve at axilla | 11.1 (4.6) n = 49 | 8.5 (1.9) n = 56 | 0.000* |
| Ulnar nerve at wrist | 5.1 (1.4) n = 67 | 5.0 (2.0) n = 56 | 0.705 |
| Ulnar nerve at forearm | 5.9 (1.6) n = 67 | 5.5 (1.5) n = 56 | 0.262 |
| Ulnar nerve at elbow | 9.3 (2.5) n = 67 | 7.8 (2.1) n = 56 | 0.000* |
| Ulnar nerve at arm | 7.7 (2.3) n = 67 | 6.2 (1.5) n = 56 | 0.000* |
| Ulnar nerve at axilla | 7.1 (2.0) n = 49 | 6.2 (1.5) n = 56 | 0.014 |
| Radial nerve at spiral groove | 5.5 (2.0) n = 65 | 4.8 (1.7) n = 56 | 0.034 |
| Posterior interosseous nerve | 2.1 (0.7) n = 60 | 1.9 (0.7) n = 56 | 0.109 |
| Brachial plexus at supraclavicular space | 97.5 (25.2) n = 52 | 65.5 (16.2) n = 46 | 0.000* |
| C5 root | 6.9 (2.3) n = 55 | 5.9 (1.5) n = 54 | 0.007 |
| C6 root | 9.7 (2.5) n = 55 | 7.8 (2.2) n = 54 | 0.000* |
| C7 root | 10.6 (3.1) n = 51 | 8.9 (1.9) n = 53 | 0.001* |
| Fibular nerve at fibular head | 9.4 (2.8) n = 65 | 8.0 (2.3) n = 56 | 0.003 |
| Fibular nerve at popliteal fossa | 7.9 (2.7) n = 65 | 6.6 (1.8) n = 56 | 0.002* |
| Tibial nerve at tarsal tunnel | 10.2 (3.6) n = 60 | 9.5 (1.9) n = 52 | 0.185 |
| Tibial nerve at popliteal fossa | 25.1 (6.2) n = 61 | 23.3 (4.8) n = 52 | 0.083 |
| Sural nerve | 2.4 (0.6) n = 33 | 2.2 (0.7) n = 28 | 0.369 |
| Sciatic nerve at mid-thigh | 42.7 (10.1) n = 26 | 35.9 (7.6) n = 28 | 0.008 |
N patients for each group, n number of CSA measurements for each site (right and left), * significant after multiple comparisons correction