Table 4.
Nerve ultrasound CSA in TTR-PN patients among the different mutations (mutations with ≤ 2 subjects with polyneuropathy are not included)
| Site | Mean and standard deviation (mm3) of nerve CSA | |||
|---|---|---|---|---|
| Phe64Leu | Val30Met | Glu89Gln | Thr49Ala | |
| Median nerve at wrist | 9.9 (2.1) N = 15 | 8.8 (1.1) N = 20 | 11.1 (3.1) N = 14 | 8.3 (2.5) N = 8 |
| Median nerve at forearm | 6.7 (2.1) N = 15 | 7.3 (2.0) N = 20 | 6.9 (2.0) N = 14 | 5.3 (1.7) N = 8 |
| Median nerve at elbow | 9.5 (2.4) N = 15 | 11.6 (4.1) N = 20 | 10.9 (2.3) N = 14 | 8.4 (2.0) N = 8 |
| Median nerve at arm | 10.8 (2.2) N = 15 | 12.5 (4.5) N = 20 | 9.6 (2.4) N = 14 | 8.5 (1.6) N = 8 |
| Median nerve at axilla | 11.4 (3.3) N = 9 | 13.4 (8.4) N = 10 | 11.6 (3.0) N = 14 | 9.6 (2.5) N = 8 |
| Ulnar nerve at wrist | 5.3 (1.6) N = 15 | 4.9 (1.1) N = 20 | 5.9 (1.7) N = 14 | 4.8 (1.4) N = 8 |
| Ulnar nerve at forearm | 6.2 (1.0) N = 15 | 6.5 (1.8) N = 20 | 5.4 (1.3) N = 14 | 5.4 (2.5) N = 8 |
| Ulnar nerve at elbow | 10.1 (2.6) N = 15 | 10.1 (2.7) N = 20 | 7.9 (2.0) N = 14 | 9.0 (1.3)N = 8 |
| Ulnar nerve at arm | 7.8 (2.4) N = 15 | 8.6 (2.6) N = 20 | 7.4 (1.9) N = 14 | 7.6 (1.8) N = 8 |
| Ulnar nerve at axilla | 7.7 (2.4) N = 9 | 7.9 (2.2) N = 10 | 6.6 (2.2) N = 14 | 7.3 (1.3) N = 8 |
| Radial nerve at spiral groove | 5.9 (1.7) N = 15 | 6.4 (2.3) N = 18 | 5.4 (1.9) N = 14 | 4.5 (1.5) N = 8 |
| Posterior interosseus nerve | 2.2 (0.7) N = 13 | 2.1 (0.6) N = 16 | 2.4 (0.7) N = 13 | 1.8 (0.5) N = 8 |
| Brachial plexus at supraclavicular space | 85.6 (8.0) N = 8 | 110.3 (27.9) N = 16 | 103.4 (23.6) N = 14 | 83.3 (17.3) N = 8 |
| C5 root | 7.3 (3.1) N = 10 | 7.8 (1.5) N = 13 | 6.1 (2.2) N = 14 | 7.4 (3.1) N = 8 |
| C6 root | 10.1 (3.5) N = 10 | 9.6 (2.1) N = 13 | 9.2 (2.1) N = 14 | 9.4 (2.8) N = 8 |
| C7 root | 9.9 (3.5) N = 9 | 11.7 (3.6) N = 13 | 10.8 (3.4) N = 14 | 9.9 (1.5) N = 8 |
| Fibular nerve at fibular head | 10.2 (2.5) N = 15 | 10.0 (3.3) N = 18 | 7.9 (2.5) N = 14 | 9.4 (2.1) N = 8 |
| Fibular nerve at popliteal fossa | 9.3 (4.1) N = 15 | 7.9 (2.1) N = 18 | 7.1 (2.2) N = 14 | 7.3 (1.0) N = 8 |
| Tibial nerve at tarsal tunnel | 9.9 (2.7) N = 12 | 11.8 (5.3) N = 16 | 10.0 (2.9) N = 14 | 9.6 (2.9) N = 8 |
| Tibial nerve at popliteal fossa | 24.9 (6.0) N = 13 | 28.7 (6.5) N = 16 | 23.6 (4.8) N = 14 | 24.1 (3.6) N = 8 |
| Sural nerve | 3.0 (0.6) N = 7 | 2.1 (0.6) N = 10 | 2.3 (0.5) N = 7 | 2.3 (0.5) N = 8 |
| Sciatic nerve at mid-thigh | – N = 0 | 53.3 (10.5) N = 6 | 43.3 (7.7) N = 6 | 38.2 (10.1) N = 8 |
SD standard deviation, PN polyneuropathy, N number of CSA measurements (right and left)