Table 5.
Risk of discontinuation of treatment
| Variable | Overall cohort | Complete switch cohort | ||
|---|---|---|---|---|
| HR (95% CI) | p value (Wald test) | HR (95% CI) | p value (Wald test) | |
| Model 1 | ||||
| Medication (reference LAI) | ||||
| Oral | 1.89 (1.73–2.06) | < 0.001 | 1.19 (1.00–1.42) | 0.050 |
| Age | 1.00 (0.99–1.00) | 0.226 | 0.99 (0.99–1.00) | 0.100 |
| Sex (reference men) | ||||
| Women | 1.12 (0.94–1.33) | 0.208 | 1.17 (0.84–1.63) | 0.359 |
| CCI | 1.04 (1.00–1.07) | 0.023 | 1.09 (1.02–1.16) | 0.007 |
| Model 2 | ||||
| Medication (reference LAI) | ||||
| Oral | 1.87 (1.70–2.05) | < 0.001 | 1.08 (0.89–1.31) | 0.453 |
| Age | 1.00 (0.99–1.00) | 0.124 | 0.99 (0.99–1.00) | 0.163 |
| Sex (reference men) | ||||
| Women | 1.14 (0.96–1.36) | 0.136 | 1.25 (0.88–1.76) | 0.210 |
| CCI | 1.04 (1.00–1.08) | 0.026 | 1.08 (1.01–1.15) | 0.032 |
| Insurance status (reference retired person) | ||||
| No compulsory insurance | 1.18 (0.65–2.15) | 0.582 | 1.48 (0.37–5.99) | 0.581 |
| Compulsory insurance | 0.94 (0.83–1.05) | 0.258 | 1.06 (0.85–1.34) | 0.603 |
| Voluntary insurance | 0.97 (0.83–1.13) | 0.676 | 1.06 (0.76–1.48) | 0.720 |
| Unemployed person | 1.07 (0.92–1.24) | 0.397 | 1.14 (0.87–1.49) | 0.346 |
| Pension claimant | 0.44 (0.21–0.92) | 0.030 | 0.35 (0.09–1.41) | 0.138 |
| Special group of persons | 1.15 (0.79–1.67) | 0.460 | 1.09 (0.48–2.47) | 0.835 |
| Family member | 0.86 (0.71–1.04) | 0.110 | 0.78 (0.52–1.16) | 0.214 |
| Unknown | 0.99 (0.84–1.17) | 0.938 | 1.09 (0.79–1.50) | 0.614 |
| Medication costs (pre-index)a | 0.99 (0.97–1.01) | 0.395 | 1.02 (0.94–1.11) | 0.606 |
| Visit costs (pre-index)a | 1.02 (0.99–1.05) | 0.258 | 1.12 (0.98–1.29) | 0.105 |
| Psychiatric inpatient stay costs (pre-index)a | 1.00 (0.99–1.00) | 0.070 | 0.99 (0.98–1.00) | 0.014 |
AIC for model 1 is 32,189 for overall cohort and 7313 for complete switch cohort. AIC for model 2 is 32,194 for overall cohort and 7318 for complete switch cohort
In insurance status, although pension claimant is seen to significantly affect the risk of treatment discontinuation, we have not considered it. In Germany, a ‘pension claimant’ is defined as a person who has applied to receive pension. Once the application is successful, the status of the person changes to ‘retired’, which was the reference category for the analysis
AIC Akaike Information Criterion, CI confidence interval, LAI long-acting injectable
aCosts transformed to €1000