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. 2020 Nov 8;80(2):250–260. doi: 10.1136/annrheumdis-2020-218493

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Corticosterone production (pmol/mg tissue/hour) in (A) fibroblast-like synoviocytes (FLS) and osteoblasts (OBs) cultures and (B) liver and spleen ex vivo biopsies isolated from tumour necrosis factor (TNF)-tg and TNF-tg^{11βflx/tw2cre} mice determined by scanning thin layer chromatography. (C) Adrenal weights (mg), (D) total clinical scores (AU), (E) arthritic paw scores (arbitrary units (AU)), (F) serum IL-6 determined by ELISA, (G) histological scoring (AU) and (H) representative images of synovitis at the ulna/humerus joint interface, (I) histological scoring (AU) and (J) representative images of TRAP stained osteoclast numbers at the ulna/humerus joint interface, (K) quantification of bone erosion (AU) in the wrist, metacarpals and phalanges and (L) representative images of three-dimensional reconstructions of front paws in TNF-tg and TNF-tg TNF-tg^{11βflx/tw2cre} animals receiving either vehicle or corticosterone (100 µg/mL) in the drinking water for 3 weeks. Values are expressed as mean±SE, n=6 per group. Statistical significance was determined using two-way analysis of variance with Tukey post hoc analysis. *P<0.05, **p<0.005, ***p<0.001.