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. 2021 Jan 6;8:613540. doi: 10.3389/fcell.2020.613540

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Copyright © 2021 Dal Molin, Hofmans, Gaffo, Buratin, Cavé, Flotho, de Haas, Niemeyer, Stary, Van Vlierberghe, Philippé, De Moerloose, te Kronnie, Bresolin, Lammens and Bortoluzzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circular to linear proportion (CLP) dysregulated in JMML compared to healthy donors. The 61 circRNAs with high absolute expression (normalized read count ≥ 100) and CLP (≥0.1) in JMML or HD for which the proportion of circular expression over the total (linear and circular) expression in JMML was at least two times increased or decreased compared to HD (|LFC(CLP)| ≥ 1). The plot shows the LFC observed comparing JMML with HD absolute linear and circular expressions (blue and pink bars, respectively) and CLP (dashed gray line). HD, healthy donors; LFC, log₂(Fold Change).