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. 2021 Jan 6;8:613540. doi: 10.3389/fcell.2020.613540

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Copyright © 2021 Dal Molin, Hofmans, Gaffo, Buratin, Cavé, Flotho, de Haas, Niemeyer, Stary, Van Vlierberghe, Philippé, De Moerloose, te Kronnie, Bresolin, Lammens and Bortoluzzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predicted circMCTP1-miRNA-gene network. (A) CircMCTP1 (red circle) is linked to miRNAs (diamonds) according to binding sites predicted by both miRanda and PITA tools; names in bold and blue indicate, respectively, miRNAs expressed in JMML (Leoncini et al., 2016) and with tumor suppressor role according to literature data; recently identified miRNAs with at least three predicted binding sites are also reported; size of circMCTP1-miRNA edges is proportional to the number of the predicted binding sites for that miRNA (range 1–4); validated miRNA target genes resulting from Mienturnet (strong MiRTarBase categories) are shown as squares, with fill color indicating the LFC of the gene expression variation comparing JMML with HD. (B) In JMML patients expression of eight genes in the network was strongly correlated (ρ ≥ 0.4) with circMCTP1 level.