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. 2021 Jan 6;8:609683. doi: 10.3389/fcell.2020.609683

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Copyright © 2021 La Spina, Contreras, Rissone, Meena, Jeong and Martina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phylogenetic relationships of the different MiT/TFE family members. Evolutionary comparison of different members of the MiT/TFE protein family represented in a phylogenetic rooted tree generated using MEGA X program (ver. 10.1.8) with a Maximum Likelihood and JTT matrix-based model and 1,000 bootstrap replicates (Jones et al., 1992; Kumar et al., 2018). The tree with the highest log likelihood (–17751.05) is shown. The percentage of trees in which the associated taxa clustered together is shown next to each branch. The tree is drawn to scale, with branch lengths measured in the number of substitutions per site. The scale of the branch lengths is indicated below the tree. The four MiT/TFE members are highlighted in different colors. Mammalian proteins are highlighted in darker colors. Ce, Caenorhabditis elegans; Dm, Drosophila melanogaster; Dr, Danio rerio; Gg, Gallus gallus; Hs, Homo sapiens; L, long; Mm, Mus musculus; P1-3, protein 1–3; Pc, Phasianus colchicus; S, short; Sh, Strigops habroptila; Xt, Xenopus tropicalis.