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. 2021 Jan 6;8:609683. doi: 10.3389/fcell.2020.609683

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Copyright © 2021 La Spina, Contreras, Rissone, Meena, Jeong and Martina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequence conservation of MiT/TFE transcription factors across species. Clustal Omega multiple sequence alignment of MiT/TFE proteins from Homo sapiens (Hs), Danio rerio (Dr), Drosophila melanogaster (Dm), and Caenorhabditis elegans (Ce). Shaded boxes highlight the degree of conservation of key functional domains between all proteins and species. Arrowheads indicate posttranslational modifications described in human TFEB, showing different degrees of conservation between species. Phosphorylation at serines 3, 138, 142, 211, 462, 463, 467, and 469; Acetylation at lysines 116, 219, 274, and 279; Sumoylation at lysine 346. Diamonds () point out leucine residues 298, 305, 312, and 319 important for the leucine zipper domain function. Note that the N-terminal sequences of some of the proteins analyzed were omitted due to the figure size constraints.

Inline graphic — Sequence conservation of MiT/TFE transcription factors across species. Clustal Omega multiple sequence alignment of MiT/TFE proteins from Homo sapiens (Hs), Danio rerio (Dr), Drosophila melanogaster (Dm), and Caenorhabditis elegans (Ce). Shaded boxes highlight the degree of conservation of key functional domains between all proteins and species. Arrowheads indicate posttranslational modifications described in human TFEB, showing different degrees of conservation between species. Phosphorylation at serines 3, 138, 142, 211, 462, 463, 467, and 469; Acetylation at lysines 116, 219, 274, and 279; Sumoylation at lysine 346. Diamonds () point out leucine residues 298, 305, 312, and 319 important for the leucine zipper domain function. Note that the N-terminal sequences of some of the proteins analyzed were omitted due to the figure size constraints.