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. 2021 Jan 6;8:609683. doi: 10.3389/fcell.2020.609683

FIGURE 7.

FIGURE 7

The stress response to pathogen infection and inflammation is modulated by MiT/TFE transcription factors. (A) In C. elegans, the activation of helix-loop-helix transcription factor 30 (HLH-30) is mediated by S. aureus and pore-forming toxin Cry5B. (B) In mammalian macrophages, TFEB and TFE3 activation is regulated by many different stimuli. Activated TFEB and TFEB3 upregulate the expression of genes involved in autophagy/lysosome-related processes and inflammatory cytokine/chemokine production. AKT, v-Akt murine thymoma viral oncogene homolog; AMPK, AMP-activated protein kinase; BECN1, beclin-1; FLCN, folliculin; HIV, human immunodeficiency virus; HMOX1, heme oxygenase 1; IFNγ, interferon γ; IFNγR, interferon γ receptor; LPS, lipopolysaccharide; Mtb, M. tuberculosis; Nef, negative regulatory factor; PKCα, protein kinase C alpha; PKD, protein kinase D; PLC, phospholipase C; TLR4, Toll-like receptor 4; TLR8, Toll-like receptor 8.