Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 6;8:609683. doi: 10.3389/fcell.2020.609683

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 La Spina, Contreras, Rissone, Meena, Jeong and Martina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Longevity and survival are promoted by MiT/TFE transcription factors. The MiT/TFE transcription factors control longevity and survival, inducing correct development, promoting healthy aging, and preventing cognitive decline. In C. elegans, helix-loop-helix transcription factor 30 (HLH-30) regulates life span extension in starvation-induced adult reproductive diapause conditions. During development, MiT/TFE proteins regulate differentiation of the eye and epidermis pigmented cells in D. melanogaster and proper vertebra formation during embryogenesis in zebrafish notochord. In addition, MiT/TFE proteins repress myelinization and induce autophagy and lysosome integrity to face aging neuronal decline in neurodegenerative lysosomal storage disorders and aberrant protein accumulation.