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. 2021 Jan 19;12:447. doi: 10.1038/s41467-020-20666-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematics showing the workflow: E14.5 in utero ICV of AAV2/5-NKCC1 or AAV2/5-GFP, followed by ICV of kaolin at P4, and MRI at P14. b Representative sequential brain images (rostral to caudal) by T2-weighted live MRI images. Blue arrows: Lateral ventricle (LV). Red arrows: kaolin. c 3D reconstruction of the LV and kaolin deposition. LV: blue. Kaolin: red. d Lateral ventricle volumes. N = 3 from two biologically independent litters under each condition; Gray: AAV-GFP mice with kaolin; purple: AAV-NKCC1 mice with kaolin. *p = 0.0.0235; Welch’s two-tailed unpaired t-test. All quantitative data are presented as mean ± SD.