Table 1.
Enriched KEGG pathways for DEGs between anagen and telogen.
| Pathways | FDR corrected P-value | Percentage enrichment | Genes |
|---|---|---|---|
| Cytokine-cytokine receptor interaction | 1.10E−11 | 14.24149 | CCL2, TNFSF12, LIF, CD40LG, IL10RA, TNFSF14, IL1F10, IL36RN, CD4, CCR2, CCR4, CCR7, IL1A, TNFSF13B, CSF2RB, CCL5, CSF1R, CCR10, THPO, CXCR3, INHBB, OSM, CXCR6, CCL14, IFNE, IL36G, TNFSF4, TGFB1, IL5RA, ACVRL1, IL2RB, IL7R, CD40, LTB, LTA, FASLG, TNFRSF1B, EPOR, IL2RA, BMP5, CXCL5, ACKR4, CCL19, IL21R, CLCF1, TNFRSF6B |
| PI3K-Akt signaling pathway | 3.24E−07 | 10.72386 | PCK2, ITGA9, COL4A1, PDGFRB, CSF1R, LAMA2, ITGA5, ITGA11, LAMB2, FLT1, THBS4, THBS2, PIK3CG, PIK3R5, OSM, JAK3, FGF16, ANGPT4, IGF2, IGF1R, NOS3, ITGB7, IL7R, FASLG, COL4A2, TNC, LAMC3, KITLG, COL6A3, EPOR, IL2RA, IL2RB, FN1, ITGAV, F2R, EREG, CREB3L4, VWF, COL6A2, LPAR6 |
| ECM-receptor interaction | 7.52E−07 | 20.68966 | COL4A1, ITGA9, LAMA2, COL6A2, FN1, ITGB7, THBS4, HSPG2, THBS2, ITGA5, ITGAV, ITGA11, COL4A2, TNC, LAMC3, VWF, LAMB2, COL6A3 |
| Cell adhesion molecules (CAMs) | 9.32E−07 | 15.09434 | ITGA9, CDH15, CLDN15, NRCAM, CD34, CD4, CD226, CD2, L1CAM, CD40LG, CD86, ICAM1, ITGAL, CDH5, CDH4, CLDN7, ITGB2, ITGB7, CD40, CD8A, ITGAV, PTPRC, ITGAM, ESAM |
| Neuroactive ligand-receptor interaction | 6.92E−06 | 9.917355 | PTH1R, CCK, GABRR2, CHRNA10, C5AR1, ADCYAP1, P2RX1, UTS2R, GPR35, MC4R, ADORA2B, CNR2, ADRB1, TAC1, RXFP2, P2RY10, ADRA2A, PTGER3, GAL, HRH2, C3, VIPR2, GRM2, TBXA2R, GRID2, OXT, PMCH, F2RL3, S1PR4, APLNR, C3AR1, DRD5, NPB, F2R, HCRTR1, LPAR6 |
| Focal adhesion | 8.17E−06 | 12.62626 | ITGA9, COL4A1, PDGFRB, LAMA2, ITGA11, LAMB2, FLT1, THBS4, THBS2, PARVB, PARVG, IGF1R, RAC2, ITGB7, SHC3, ITGA5, COL4A2, TNC, LAMC3, VWF, FN1, VAV1, ITGAV, COL6A3, COL6A2 |
| NF-kappa B signaling pathway | 1.86E−05 | 16.66667 | CD40LG, TIRAP, CD14, CCL19, CARD11, TNFSF14, CD40, LTB, LTA, ZAP70, ICAM1, PRKCQ, RELB, LYN, LAT, BTK, TNFSF13B |
| Rap1 signaling pathway | 3.10E−05 | 11.57407 | RASGRP2, PDGFRB, APBB1IP, PLCB2, GNAI2, FLT1, ADORA2B, ARAP3, RAP1GAP, CSF1R, SIPA1, FGF16, ANGPT4, IGF1R, ITGB2, RAC2, LAT, LCP2, KITLG, ADCY4, VAV1, F2R, ITGAL, ITGAM, F2RL3 |
| cAMP signaling pathway | 0.000169188 | 10.52632 | NFATC1, ADCYAP1, ATP2A3, ADCY10, RAC2, GNAI2, ARAP3, ADRB1, CNGB3, CAMK4, PTGER3, VIPR2, NPR1, LIPE, OXT, CNGA3, PDE10A, ADCY4, VAV1, DRD5, F2R, CREB3L4, PDE4A, CFTR |
| MAPK signaling pathway | 0.00685971 | 7.876712 | RASGRP2, NFATC1, RASGRP4, PDGFRB, TGFB1, IL1A, FLT1, CACNA1H, CSF1R, DUSP9, RELB, FGF16, ANGPT4, IGF2, IGF1R, RAC2, STK3, FASLG, KITLG, PTPN7, RPS6KA2, CD14, EREG |
| Calcium signaling pathway | 0.006925474 | 8.866995 | ORAI2, TBXA2R, ADORA2B, NOS3, F2R, PLCB2, ADCY4, DRD5, CAMK4, PDGFRB, PTGER3, ITPKA, ADRB1, GNA14, HRH2, CACNA1H, P2RX1, ATP2A3 |
| Ras signaling pathway | 0.0081218 | 8.264463 | IGF2, RASGRP2, IGF1R, RAC2, RASGRP4, SHC3, PLA2G12B, CSF1R, FGF16, PLA2G2E, ZAP70, PLA2G2F, LAT, FASLG, KITLG, RASA3, PDGFRB, RASAL3, ANGPT4, FLT1 |
| Protein digestion and absorption | 0.01083711 | 10.61947 | COL15A1, SLC9A3, KCNQ1, COL5A3, KCNN4, COL13A1, COL4A2, COL4A1, COL24A1, COL6A3, COL6A2, SLC1A1 |
| Arachidonic acid metabolism | 0.011034945 | 12.04819 | PTGS1, TBXAS1, PLA2G12B, ALOX5, EPHX2, PTGIS, ALOX15, PLA2G2E, PLA2G2F, PTGES |
| Melanogenesis | 0.014067417 | 10.78431 | WNT2B, ADCY4, PLCB2, CREB3L4, WNT3, WNT2, WNT9A, FZD9, WNT5B, KITLG, GNAI2 |
| Hippo signaling pathway | 0.014200591 | 9.271523 | WNT2B, TGFB1, BMP5, ITGB2, WNT3, WNT2, STK3, WNT9A, FZD9, DLG2, WNT5B, WTIP, SERPINE1, CTNNA3 |
| cGMP-PKG signaling pathway | 0.014896486 | 8.87574 | ADCY4, NFATC1, PLCB2, NOS3, NFATC4, NPR1, ATP2A3, KCNJ8, ADRA2A, PIK3CG, ADRB1, PIK3R5, CREB3L4, PDE2A, GNAI2 |
| Phospholipase D signaling pathway | 0.014927328 | 9.210526 | ADCY4, PDGFRB, FCER1G, FCER1A, SHC3, MS4A2, PLCB2, PIK3CG, F2R, PIK3R5, KITLG, LPAR6, CYTH4, GRM2 |
| Wnt signaling pathway | 0.021435141 | 8.695652 | WNT2B, NFATC1, PLCB2, NFATC4, RSPO4, WNT3, WNT2, LGR5, SOX17, RSPO2, WNT9A, FZD9, WNT5B, RAC2 |
| Jak-STAT signaling pathway | 0.025691752 | 7.920792 | IL7R, IL2RA, IL2RB, STAT4, SOCS1, IL10RA, PDGFRB, IFNE, IL21R, IL5RA, THPO, LIF, OSM, JAK3, CSF2RB, EPOR |
| Signaling pathways regulating pluripotency of stem cells | 0.035422505 | 8.633094 | WNT2B, LIF, PCGF6, WNT3, WNT2, IGF1R, INHBB, DUSP9, JAK3, WNT9A, FZD9, WNT5B |
| Purine metabolism | 0.049889538 | 8.148148 | ADCY4, PKLR, ENTPD2, NPR1, ADA2, AK5, PDE2A, PDE6A, ADCY10, PDE4A, PDE10A |