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. 2021 Jan 19;11:1788. doi: 10.1038/s41598-020-79892-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Selectivity of indeno[1,2-b]indole derivatives toward ABCG2. (A, B) Effect of compounds at 1 and 10 µM on ABCB1 (P-gp) for rhodamine 123 transport inhibition and on ABCC1 (MRP1) for calcein-AM transport inhibition. The data are the mean ± SD of three independent experiments performed in duplicate and compared using the Student's t test (2-sided) for independent samples. *p < 0.05 were considered significant for all tests.