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. 2021 Jan 19;11:1812. doi: 10.1038/s41598-021-81382-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Serum IL-10 and TNF-α concentrations and the serum IL-10/TNF-α ratio with a KL grade = 3 (moderate knee osteoarthritis, ≤ 50% joint space narrowing, n = 49) compared to a KL grade = 4 (severe knee osteoarthritis, > 50% joint space narrowing, n = 30). (A) Serum IL-10 was significantly (^ap < 0.05 vs. KL grade = 3) lower with a KL grade = 4. (B) Serum TNF-α concentrations were not significantly different between groups. (C) The serum IL-10/TNF-α ratio was significantly (^ap < 0.05 vs. KL grade = 3) lower with a KL grade = 4. Data presented as median (interquartile range).