Table 3.
Summary of algorithm performance in the prospective validation cohort.
| Category | n | Above Threshold | Call Rate (%) | Sensitivity in Top 1 (%) | Sensitivity in Top 2 (%) | Sensitivity in Top 3 (%) | Sensitivity in Top 4 (%) | Sensitivity in Top 5 (%) | Rule Outs / Case | Rule Out Accuracy (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| Global | 13,661 | 12,699 | 93 | 94.7 | 97.2 | 97.9 | 98.1 | 98.2 | 17.6 | 99.9 |
| Primary Specimen | 7521 | 7087 | 94.2 | 96.1 | 98.2 | 98.7 | 98.8 | 98.9 | 17.8 | 100 |
| Metastatic Specimen | 5942 | 5426 | 91.3 | 93 | 96 | 97 | 97.2 | 97.4 | 17.4 | 99.9 |
| Percent Tumor < 20 | 4 | 3 | 75 | 100 | 100 | 100 | 100 | 100 | 18.7 | 100 |
| Percent Tumor >= 20, <= 50 | 8227 | 7636 | 92.8 | 94.5 | 97 | 97.8 | 97.9 | 98 | 17.4 | 99.9 |
| Percent Tumor > 50, <= 80 | 5189 | 4835 | 93.2 | 95 | 97.7 | 98.2 | 98.4 | 98.5 | 17.9 | 100 |
| Percent Tumor > 80 | 241 | 225 | 93.4 | 96 | 96.4 | 96.4 | 96.4 | 96.9 | 18 | 99.9 |