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. 2020 Sep 18;12(1):29–38. doi: 10.1007/s13238-020-00786-8

Figure 3.

Figure 3

Noncoding mutations converge onto FOXA1. FOXA1 locus is frequently altered by structural rearrangements inclusive of translocations and tandem duplications. Translocations can result in genes hijacking the activity of the FOXMIND enhancer. In addition, translocations can insert oncogenes upstream of FOXA1. Along with FOXMIND, 5 additional functional CREs harbouring SNVs are identified near FOXA1 locus which can affect the expression of FOXA1. The 3′ UTR region of FOXA1 is frequently mutated with indels being the dominant type of mutation. Abbreviations: SNV, single nucleotide variant; 3′ UTR, 3′ untranslated region; CRE, cis-regulatory elements