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. 2020 Dec 9;76(2):152–160. doi: 10.1136/thoraxjnl-2020-215520

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Individuals with interstitial lung abnormalities (ILA) display high levels of pro-inflammatory cytokines in plasma. Plasma was obtained and prepared to measure several soluble proteins by ELISA. Plasma concentrations of IFN-γ, IL-6, IL-10, E-cadherin and granzyme B were evaluated (panel A, B, C, D and E, respectively). Graphs show individual value mean±SD (young: n=16, old: n=15, old+ILA: n=11). *p<0.05 **p<0.01. Statistical analysis was performed with an one-way analysis of variance test adjusted by the Dunnett method; asterisks indicate comparison of the three groups. When the asterisk is on a line, indicates, the comparison between old control group and old+ILA. IFN-γ, interferon gamma; IL, interleukin.