Figure 4.

Associations between gene GPR151 and microbial pathways. (A) Meta p values based on burden test between 30 genes with rare protein truncating variants (PTVs) on chromosome 5 and relative abundance of MetaCyc pathway homolactic fermentation (top). Blue dot represents meta p value of gene GPR151. Lower panel shows the variants found along with the coding region in GPR151. Different colours indicate different variant categories. Red indicates two rare stop-gain mutations, rs114285050 and rs140458264. (B) Box plots for associations between the relative abundance of the homolactic fermentation (meta p=4.78 $\times$ 10⁻⁶, FDR<0.05), glucose xylose degradation (meta p=3.05 $\times$ 10⁻⁵, FDR<0.05) microbial pathways and GPR151, respectively. b, effect size. GPR151, without rare PTVs. GPR151*, with rare PTVs.