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. 2020 Dec 3;76(2):144–151. doi: 10.1136/thoraxjnl-2019-214375

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Representative parametric transit time (FWHM) maps from two participants each with baseline (A and C) and follow up (B and D) scans. Participant 12 (A and B) demonstrates an increase in FWHM in the right lower lobe and left mid-zone peripheral lung tissue. FWHM_mean decreased slightly by 0.13 s, with associated changes in FVC from 60.1% to 63.2%, and TL_CO from 37.1% to 33.0%, respectively. Participant 18 (C and D) shows a gross overall increase in FWHM, again worse in peripheral lung tissue. FWHM_mean increased by 4.35 s, in spite of both FVC and TL_CO remaining relatively stable from 76.0% to 74.5%, and from 87.2% to 88.2%, respectively. Colour bar denotes FWHM in seconds. FVC, forced vital capacity; FWHM, full width at half maximum; FWHM_mean, mean FWHM;TL_CO, diffusingcapacity of the lungs for carbon monoxide.