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. 2021 Jan 19;4:82. doi: 10.1038/s42003-020-01606-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Our platform favors an autologous cell therapy approach where human BMSCs are isolated from bone marrow of ilium and expanded in vitro. BMSCs are then engineered with modified mRNAs and are inoculated into scaffolds, which are implanted into human bone (cranial) defect sites.