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. 2020 Dec 29;2(1):100177. doi: 10.1016/j.patter.2020.100177

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The Hide- and Tag-Methods Enable the Study of the Relations between the Most Relevant Metabolites and Reactions

For a Figure360 author presentation of this figure, see https://doi.org/10.1016/j.patter.2020.100177.

(A) Information about the production of F can be ignored if F is marked as internal and a virtual reaction (cyan) is added that converts metabolite F into nothing. This strategy aids in fast computation, because the resulting set of ECMs is generally smaller (see also the worked-out example in Methods).

(B) Information about the usage of a reaction can be uncovered by coupling the production of a virtual metabolite (T₁, shown in green). The coefficient of T₁ in the resulting ECMs denotes the rate of the reaction of interest.