Figure 2. Least-Square Mean (SE) Difference of Preclinical Alzheimer Cognitive Composite (PACC) (A) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) (B) Decline (Intention-to-Treat [ITT] Analysis Set).

A, PACC is defined as the sum of transformed z scores for each of the 4 components of the measure: sum of free and total recall on the Free and Cued Selective Reminding Test, Delayed Paragraph Recall score on Logical Memory from the Wechsler Memory Scale, Digit-Symbol Coding Subtest (Wechsler Adult Intelligence Scale IV); and Mini-Mental State Examination (MMSE) total score. A decrease of 1 baseline standard deviation on each component would result in a 4-point decrease in the composite. B, RBANS consists of 12 subtests measuring the following 5 indices (domains): attention, language, visuospatial/construction, immediate memory, and delayed memory.

^aP < .001.