REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
HSP-6	Abmart	Cat# X-P11141-N, RRID:AB_2885192
ATP-5	Abcam	Cat# ab110413, RRID:AB_2629281
UCR-1	Abcam	Cat# ab110413, RRID:AB_2629281
CTC-1	Abcam	Cat# ab110413, RRID:AB_2629281
GAPDH (14C10)	Cell Signaling	Cat# 2118, RRID:AB_561053
APP	Abcam	Cat# ab32136, RRID:AB_2289606
SDHB	Abcam	Cat# ab110413, RRID:AB_2629281
MTCO1	Abcam	Cat# ab14705, RRID:AB_2084810
4G8	Biolegend	Cat# 800701, RRID:AB_2564633
anti-Oligomer (A11)	Thermo Scientific	Cat# AHB0052, RRID:AB_2536236
Laminin	Sigma	Cat# L9393, RRID:AB_477163
Bacterial and virus strains
atfs-1 RNAi	Vidal library	11070-E7; ZC376.7
dct-1 RNAi	Ahringer library	X-4G11; C14F5.1
Chemicals, peptides, and recombinant proteins
Nicotinamide riboside triflate (NR)	Novalix	http://www.novalix-pharma.com/
Olaparib (AZD2281)	Glentham Life Sciences	763113-22-0
Thioflavin T (ThT)	Sigma Aldrich	T3516-5G
Rhodamine Phalloidin	Invitrogen	219920-04-4
TMRM	Invitrogen	T668
DAPI	Invitrogen	D1306
DAKO mounting medium	DAKO	S3023
Hoechst	Invitrogen	C10340
Paraquat	Sigma Aldrich	856177
Lipofectamine 2000	Thermo	11668019
TRIzol	Life technologies	15596026
FK866	Sigma Aldrich	F8557-5MG
Critical commercial assays
Proteostat® Aggresome Detection kit	Enzo life sciences	ENZ-51035-K100
LightCycler 480 SYBR Green I Master reagent	Roche Life Science	04887352001
Experimental models: cell lines
Human primary myoblasts	Hospices Civils de Lyon	N/A
C2C12 ev or APPSwe	Generated in house	N/A
Experimental models: organisms/strains
C. elegans N2	Caenorhabditis Genetics Center	WormBase ID: WBStrain00000001
C. elegans SJ4103 (myo-3::GFP(mit))	Caenorhabditis Genetics Center	WormBase ID: WBStrain00034069
C. elegans GMC101 (unc-54p::A-beta-1-42::unc-54 3′-UTR + mtl-2p::GFP)	Caenorhabditis Genetics Center	WormBase ID: WBStrain00007866
C. elegans CL2122 ((pPD30.38) unc-54(vector) + (pCL26) mtl-2::GFP)	Caenorhabditis Genetics Center	WormBase ID: WBStrain00005101
C. elegans RW1596 (myo-3p::GFP)	Caenorhabditis Genetics Center	WormBase ID: WBStrain00033508
C. elegans AUW15: (cross GMC101+SJ4103)	Generated in house	N/A
C. elegans AUW14: (cross CL2122+SJ4103)	Generated in house	N/A
Mouse C57BL/6JRj	Janvier Labs	https://www.janvier-labs.com/en/fiche_produit/aged_c57bl-6jrj_mouse/
Oligonucleotides
Primers for qPCR analysis of C. elegans samples, see Table “list of primers used in C.elegans”	This paper	N/A
Primers for qPCR analysis of mouse samples, see Table “list of primers used in Mus musculus”	This paper	N/A
Recombinant DNA
Plasmid pCAX APPSwe/Ind	Addgene	#30145
Software and algorithms
Fiji	Schindelin et al., 2012	https://imagej.net/Fiji
ImageJ	Schindelin et al., 2012	https://imagej.nih.gov/ij/
GeneBridge	Li et al., 2019	https://www.systems-genetics.org/mmad
Movement Tracker software	Mouchiroud et al., 2016	N/A