${\text{k}}_1$	controls the strength of $I1$ inhibition by $I2$	5
${\text{k}}_2$	${\text{I}}_{\text{p}}$ threshold for activating $I2$	0.05
${\text{k}}_3$	controls the strength of $I_{\text{t}}$ inhibition by $I1$	10
${\text{k}}_4$	degradation rate of ${\text{I}}_{\text{m}}$	1 /h
${\text{k}}_5$	synthesis rate of ${\text{I}}_p$	1 /h
${\text{k}}_6$	degradation rate of ${\text{I}}_p$	1 /h
$\text{r}$	Rme1 concentration	0-5
$\text{A}$	$I2$ threshold for activating $I1$	0.01