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. Author manuscript; available in PMC: 2021 Jan 20.
Published in final edited form as: Cell Metab. 2019 Oct 1;30(4):735–753.e4. doi: 10.1016/j.cmet.2019.09.003

Figure 1. Fructose and Glucose Supplementation Modifies Fatty Acid Oxidation.

Figure 1.

(A and B) Long- (A) and short-chain (B) acylcarnitine profiles measured from the livers of mice collected in the fed state after 10 weeks on respective diets. The data are represented as mean ± SEM, n = 6 mice per group. Complete names of acylcarnitines are provided in Table S2.

(C) Cpt1a mRNA expression and protein levels.

(D) CPT1a activity in isolated mitochondria and hepatic malonyl-CoA levels from the same mice. n = 8 mice per group. # denotes the significant difference as compared to the chow control, whereas * signifies the significant difference between the groups under the crossbar.

(E and F) Hepatic pAMPK and pACC1 levels.

(G) Serum FFA and β-hydroxybutyrate levels in overnight fasted mice.

(H) Oxygen consumption rate in AML-12 hepatocytes pretreated with glucose or fructose for 48 h.