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. 2021 Jan 20;28(2):557–569. doi: 10.1038/s41418-020-00702-x

Fig. 1. Schematic representation of the domain organisation of LUBAC subunits and associated DUBs.

Fig. 1

The catalytic cysteine in HOIP and HOIL are indicated with red circles and the numbering of all amino acid residues is based on the human protein. Abbreviations: B-box B-Box-type zinc finger, CAP-Gly cytoskeleton-associated protein-glycine rich, CBR catalytic in-between RING, IBR in-between-RING, CYLD cylindromatosis, HOIL-1 Heme-oxidised IRP2 Ub ligase-1, HOIP HOIL-1-interacting protein, LDD linear ubiquitin chains-determining domain, LTM LUBAC-tethering motif, LUBAC linear ubiquitin chain assembly complex, NZF nuclear protein localisation 4 (Npl4) zinc finger, OTU ovarian tumour, PH pleckstrin homology, PIM PUB-interacting motif, PUB peptide:N-glycanase/UBA- or UBX-containing proteins, RING really interesting new gene, SHARPIN Shank-associated RH domain-interacting protein, SPATA2 Spermatogenesis-associated 2, UBA ubiquitin associated, UBL ubiquitin-like, USP ubiquitin-specific protease, ZnF zinc finger. Arrows indicate domains that interact.