Table 1.

Timeline of events in the trial

	Enrollment	Allocation	Post-allocation				Discharge	Close-out
Time point	− 1	0	D1–D4	D5–D7	D8–D14	D15–D28
Enrollment
Screening	x
Eligibility criteria	x
Informed consent	x
Allocation		x
Randomization		x
Baseline data collection		x
Interventions
Icatibant/std care			x
C1 inhib./std care			x
Std care	x	x	x	x	x	x	x
Outcome/safety assessments
CT of the chest	x				X (D14)	X (D28)	X
Primary outcome			x	x	x	x	x
Clinical symptoms		x	x	x	x	x	x
Vital signs	x	x	x	x	x	x	x	x
ECG				x
Adverse events	x	x	x	x	x	x	x	x
Time mechanical ventilation								x
Death								x
Length of stay								x
Laboratory tests*	Only every 4 days or at the discretion of the assistant physician
RT-PCR SARS-CoV-2	x
Bradykinin		x	x				x
SOFA score		x	x	x	x	x	x
Blood routine		x	x	x	x	x	x
Coagulation routine		x	x	x	x	x	x
CRP		x	x	x	x	x	x
Liver function		x	x	x	x	x	x
Kidney function		x	x	x	x	x	x
d-dimer		x	x	x	x	x	x
High-sensitivity troponin		x	x	x	x	x	x
Pro-BNP		x	x	x	x	x	x
Aspergillus antigen		x	x	x	x	x