Fig. 5.

Relative proportions (mole %) of bile acids with 7-oxo or 7β-hydroxy group conjugated with GlcNAc in urine from 3 SLOS patients and 6 controls determined by LC–MS. The SLOS patients were from the group who donated plasma. See Supplemental Figure S4 for relevant chromatograms. Total bile acids include mono-, di- and tri-hydroxylated cholanoic acids and their single and doubly unsaturated equivalents singly, doubly or triply conjugated with glycine or taurine, sulfuric acid and GlcNAc. Mann-Whitney test was used for comparison of non-normally distributed data. *, P < 0.05; **, P < 0.01.