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Oxysterols bind to Smo and modulate Hh signalling across the cell membrane. (A) Cartoon representation of Smo (CRD in silver, LD in red, TMD including ECL3 in blue. (B) Molecular modeling analysis of human Smo with cholesterol bound to the CRD, based on the crystal structure in [52]. (C) Schematic representation of the Hh signalling pathway showing 7-oxosterols activating Smo.
