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. 2021 Jan 19;34(3):108661. doi: 10.1016/j.celrep.2020.108661

Figure 6.

Figure 6

CD103+ CD8+ intestinal T cells demonstrate greater capacity for cytokine production

(A–D) Cytokine production by small intestinal CD8+ T cells. Representative histograms of expression, and group summaries of proportion of CD8+ T cells expressing TNF-α (A), IFN-γ (B), CCL4 (C), and IL-2 (D) after 4 h stimulation with PMA and ionomycin in the presence of brefeldin A and monensin, categorized by CD69 and CD103 expression, in small intestinal biopsies from healthy control subjects (n = 10).

(E) Mean proportion of CD8+ T cells expressing 0, 1, 2, 3, or 4 of the cytokines/chemokines TNF-α, IFN-γ, CCL4, and IL-2, categorized by CD69 and CD103 co-expression, from small intestinal biopsies from healthy control subjects (n = 10).

(F) Mean percentage (± SEM) of CD8+ T cells co-expressing TNF-α, IFN-γ, CCL4, and/or IL-2 after PMA and ionomycin stimulation as described, categorized by CD69 and CD103 expression.

Statistical analysis performed with one-way ANOVA with Tukey’s multiple-comparison test. ∗p ≤ 0.05, ∗∗p ≤ 0.01, ∗∗∗p ≤ 0.001.