Table 2. Pharmacophore Evaluation of Pyrazolylpyrimidinones^a.

^aMIC were measured in Middlebrook 7H9/Glu/BSA/Tyloxapol media at day 7; IC₅₀—50% inhibitory concentrations; solubility—aqueous solubility measured at pH 7.4; CHO—an epithelial cell-line derived from the ovary of the Chinese hamster; and V—Vero cell-line; SI—selectivity index between CHO IC₅₀ and Mtb MIC.