. 2021 Jan 4;64(1):719–740. doi: 10.1021/acs.jmedchem.0c01727

Table 3. Polar Substitutions on Pyrimidinone^a.

MIC—were measured in Middlebrook 7H9/Glu/BSA/Tyloxapol media at day 7; IC₅₀—50% inhibitory concentrations; solubility—aqueous solubility measured at pH 7.4; CHO—an epithelial cell-line derived from the ovary of the Chinese hamster; and SI—selectivity index between CHO IC₅₀ and Mtb MIC.

Table 3. Polar Substitutions on Pyrimidinonea.

Table 3. Polar Substitutions on Pyrimidinone^a.