Table 6. In Vitro ADME Properties of Selected Compounds^d.

compound	8	12	39	40	45	47	50
clog Pa	1.82	1.36	1.30	2.52	1.46	0.66	1.54
clog Da	1.82	1.36	1.09	2.52	1.46	1.09	1.40
solubility (μM)b	120	200	50	15	25	90	160
MSc H/R/Mo % remaining after 30 min	65/54/45	>99/92/>99	>99/>99/93	98/98/96	>99/96/>99	80/95/94	ND
PPBd human fu	ND	0.006	0.014	0.013	ND	0.009	0.03

^aCalculated log P/log D (StarDrop).

^bKinetic solubility measured at pH 7.4.

^cMicrosomal stability H: human, R: rat Mo: mouse.

^dPPB; fu—fraction unbound.