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. 2020 Dec 31;64(1):481–515. doi: 10.1021/acs.jmedchem.0c01441

Table 1. Activity Data for Hit 2 and Scaffold Analogues 3–6.

graphic file with name jm0c01441_0007.jpg

ID X1 X2 X3 pIC50 ± SEM cLogPa
2 N N CH 6.09 ± 0.04 3.84
3 N CH CH 4.98 ± 0.03 4.25
4 CH N CH 5.84 ± 0.03 3.90
5 CH N N 5.39 ± 0.11 3.84
6 N N N <4.3 3.09
a

cLogP was calculated using Chemdraw 15.