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. Author manuscript; available in PMC: 2021 Jan 20.
Published in final edited form as: Cell Rep. 2020 Dec 22;33(12):108530. doi: 10.1016/j.celrep.2020.108530

Figure 6. Loss of BST2 Reduces HSC Proliferation and Increases HSC Numbers.

Figure 6.

(A) BrdU+ HSCs isolated from WT or Bst2−/− mice. Shown as % of total HSCs (LSK CD150+ CD48− CD34−). n = 4; data are representative of 2 independent experiments.

(B and C) The number of HSCs in WT or Bst2−/− mice.

(B) The % of live WBM cells.

(C) Absolute number per bone. n = 4; Data are representative of 4 independent experiments.

(D) Total peripheral blood engraftment following transplant of 2 × 105 CD45.2 WT or Bst2−/− WBM cells mixed with 2 × 105 rescue marrow (CD45.1). n = 10.

(E) Total peripheral blood engraftment following transplant of 300 CD45.2 WT or Bst2−/− HSCs mixed with 2 × 105 rescue marrow (CD45.1). n = 10. Data are presented as mean ± SEM; *p < 0.05, **p < 0.01.