Table 7.

Microsomal stability and physiochemical properties

Entry	Compound	Ar	Microsomal stability (%) b	Aq. solubility (μg/mL) b	cLogD c
1	4		0	42	1.27
2	11u		0	59	0.90
3	11y		18	52	1.28
4	11c		24	69	0.33
5	11g		35	23	1.95
6	11f		38	74	1.41
7	11w		45	51	0.77
8	11r		47	56	0.33
9	11p		63	61	0.61
10	11s		63	5	1.65
11	11h		66	55	1.49
12	11o		73	54	0.60
13	11z		88	49	0.47
14	11aa		88	57	1.49
15	11x		95	65	0.72

^a% compound remaining in mouse liver microsomes at 30 min.

^bKinetic solubility at pH 7.4.

^cCalculated LogD at pH 7.0.