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. 2021 Jan 15;14:165–184. doi: 10.2147/DMSO.S286888

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© 2021 Kalra et al.

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Mechanism of inhibition of fatty acid oxidation in mitochondria in post-prandial state. Malonyl CoA generated from acetyl CoA derived from utilization of carbohydrates through glycolysis and TCA cycle by acetyl CoA carboxylase, inhibits the entry of long-chain fatty acyl CoA into mitochondria.

Abbreviations: ATP, adenosine triphosphate; ACC, acetyl CoA carboxylase; CPT, carnitine palmitoyltransferase; FAS, fatty acyl synthase; LDH, lactate dehydrogenase; TCA, tricarboxylic acid cycle; PDH, pyruvate dehydrogenase.