Figure 3.

Combination treatments of PTX and histone deacetylase 6-selective inhibitors synergistically suppress the proliferation and migration of TOV-21G cells. (A) PTX (40 nM) and ACY-241 (4 µM) significantly inhibited the wound closure of TOV-21G cells compared with either drug alone. (B) PTX (40 nM) and A452 (2 µM) significantly inhibited the wound closure of TOV-21G cells compared with either drug treatment as monotherapy. Magnification, ×50. Data are presented as the mean ± SD (n=3). *P<0.05, **P<0.01 and ***P<0.001 vs. DMSO control; ^$$$P<0.001 vs. PTX; ^###P<0.001 vs. ACY-241 or A452 (one-way ANOVA). Ctrl, control; Combi, combination treatment; PTX, paclitaxel.