Table IV.
Associations between Twist, Snail and Slug expression and clinicopathological parameters in esophageal squamous cell carcinoma.
| Twist, n (%) | Snail, n (%) | Slug, n (%) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clinicopathological parameters | No. | Positive | Negative | P-value | χ2 | Positive | Negative | P-value | χ2 | Positive | Negative | P-value | χ2 |
| Total | 229 | 135 (59.0) | 94 (41.0) | 132 (57.6) | 97 (42.4) | 112 (49.0) | 117 (51.0) | ||||||
| Age, years | 0.208 | 1.587 | 0.661 | 0.192 | 0.801 | 0.063 | |||||||
| ≤60 | 84 | 45 (53.6) | 39 (46.4) | 50 (59.5) | 34 (40.5) | 42 (50.0) | 42 (50.0) | ||||||
| >60 | 145 | 90 (62.1) | 55 (37.9) | 82 (56.6) | 63 (43.4) | 70 (48.3) | 75 (51.7) | ||||||
| Sex | 0.040 | 4.198 | 0.99 | <0.001 | 0.616 | 0.252 | |||||||
| Male | 163 | 103 (63.2) | 60 (36.8) | 94 (57.7) | 69 (42.3) | 78 (47.9) | 85 (52.1) | ||||||
| Female | 66 | 32 (48.5) | 34 (51.5) | 38 (57.6) | 28 (42.4) | 34 (51.5) | 32 (48.5) | ||||||
| Ethnicity | 0.389 | 0.742 | 0.849 | 0.036 | 0.466 | 0.531 | |||||||
| Han | 115 | 71 (61.7) | 44 (38.3) | 67 (58.3) | 48 (41.7) | 59 (51.3) | 56 (48.7) | ||||||
| Kazakh | 114 | 64 (56.1) | 50 (43.9) | 65 (57.0) | 49 (43.0) | 53 (46.5) | 61 (53.6) | ||||||
| Tumor location | 0.616 | 0.968 | 0.785 | 0.484 | 0.269 | 2.625 | |||||||
| Upper | 11 | 5 (45.5) | 6 (54.5) | 7 (63.6) | 4 (36.4) | 8 (72.7) | 3 (27.3) | ||||||
| Middle | 136 | 80 (58.8) | 56 (41.2) | 76 (55.9) | 60 (44.1) | 65 (47.5) | 71 (52.2) | ||||||
| Lower | 82 | 50 (61.0) | 32 (39.0) | 49 (59.8) | 33 (40.2) | 39 (47.6) | 43 (52.4) | ||||||
| Tumor size | 0.302 | 1.067 | 0.441 | 0.593 | 0.607 | 0.264 | |||||||
| <3 cm | 67 | 36 (53.7) | 31 (46.3) | 36 (53.7) | 31 (46.3) | 31 (46.3) | 36 (53.7) | ||||||
| ≥3 cm | 162 | 99 (61.1) | 63 (38.9) | 96 (59.3) | 66 (40.7) | 81 (50.0) | 81 (50.0) | ||||||
| Differentiation | 0.652 | 0.856 | 0.562 | 1.153 | 0.048 | 6.068 | |||||||
| Low | 47 | 25 (53.2) | 22 (46.8) | 24 (51.1) | 23 (48.9) | 21 (44.7) | 26 (55.3) | ||||||
| Medium | 123 | 75 (61.0) | 48 (39.0) | 74 (60.2) | 49 (39.8) | 54 (43.9) | 69 (56.1) | ||||||
| High | 59 | 35 (59.3) | 24 (40.7) | 34 (57.6) | 25 (42.4) | 37 (62.7) | 22 (37.3) | ||||||
| Depth of invasion | 0.369 | 1.994 | 0.452 | 1.59 | 0.197 | 3.248 | |||||||
| Mucosal | 6 | 2 (33.3) | 4 (66.7) | 3 (50.0) | 3 (50.0) | 5 (83.3) | 1 (16.7) | ||||||
| Muscle | 94 | 54 (57.4) | 40 (42.6) | 50 (53.2) | 44 (46.8) | 43 (45.7) | 51 (54.3) | ||||||
| Full | 129 | 79 (61.2) | 50 (38.8) | 79 (61.2) | 50 (38.8) | 64 (49.6) | 65 (50.4) | ||||||
| TNM stage | 0.577 | 1.98 | 0.968 | 0.256 | 0.050 | 7.797 | |||||||
| I | 16 | 7 (43.8) | 9 (56.2) | 10 (62.5) | 6 (37.5) | 13 (81.3) | 3 (18.7) | ||||||
| II | 143 | 84 (58.7) | 59 (41.3) | 82 (57.3) | 61 (42.7) | 69 (48.3) | 74 (51.7) | ||||||
| III | 48 | 30 (62.5) | 18 (37.5) | 28 (58.3) | 20 (41.7) | 21 (43.8) | 27 (56.2) | ||||||
| IV | 22 | 14 (63.6) | 8 (36.4) | 12 (52.4) | 10 (47.6) | 9 (40.9) | 13 (59.1) | ||||||
| Lymph node metastasis | 0.863 | 0.03 | 0.695 | 0.154 | 0.306 | 1.049 | |||||||
| No | 152 | 89 (58.6) | 63 (41.4) | 89 (58.6) | 63 (41.4) | 78 (51.3) | 74 (48.7) | ||||||
| Yes | 77 | 46 (59.7) | 31 (40.3) | 43 (55.8) | 34 (44.2) | 34 (44.2) | 43 (55.8) | ||||||
| Vascular invasion | 0.362 | 0.831 | 0.678 | 0.173 | 0.017 | 5.664 | |||||||
| No | 186 | 107 (57.5) | 79 (42.5) | 106 (57.0) | 80 (43.0) | 98 (52.7) | 88 (47.3) | ||||||
| Yes | 43 | 28 (65.1) | 15 (34.9) | 26 (60.5) | 17 (39.5) | 14 (32.6) | 29 (67.3) | ||||||
| Nerve invasion | 0.62 | 0.246 | 0.481 | 0.498 | 0.432 | 0.617 | |||||||
| No | 179 | 104 (58.1) | 75 (41.9) | 101 (56.4) | 78 (43.6) | 90 (50.3) | 89 (49.7) | ||||||
| Yes | 50 | 31 (62.0) | 19 (38.0) | 31 (62.0) | 19 (38.0) | 22 (44.0) | 28 (56.0) | ||||||
| Radiotherapy or chemotherapy | 0.964 | 0.002 | 0.151 | 2.057 | 0.253 | 1.309 | |||||||
| No | 149 | 88 (59.1) | 61 (40.9) | 91 (61.1) | 58 (38.9) | 77 (51.7) | 72 (48.3) | ||||||
| Yes | 80 | 47 (58.8) | 33 (41.0) | 41 (51.3) | 39 (48.7) | 35 (43.8) | 45 (56.2) | ||||||