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. 2021 Jan 14;21(3):205. doi: 10.3892/ol.2021.12466

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Copyright: © Mo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Interaction network, biological process analysis and hierarchical clustering of the hub genes. (A) Hub genes and their co-expression genes were visualized using the cBioPortal. Nodes with bold black outlines represent hub genes. Nodes with thin black outlines represent co-expression genes. (B) Biological process analysis of hub genes was constructed using the Biological Networks Gene Oncology plug-in. Color depth of the nodes refers to the corrected P-value of ontologies. Size of the nodes refers to the numbers of genes that are involved in the ontologies. P<0.05 was considered statistically significant. (C) Hierarchical clustering of hub genes was constructed using the University of California, Santa Cruz online database. Solid tissue samples above the blue bar are non-cancerous samples and the samples under the brown bar are tumor samples. Upregulation of genes is marked in red; downregulation of genes is marked in blue.