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. 2021 Jan 19;21:82. doi: 10.1186/s12885-021-07806-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Gene expression profiles of BCOR mutant expressing cells. a Heat map of genes with 1.5-fold as well as P < 0.05 mRNA expression differences between wild-type BCOR and BCOR K607E mutant expressing cells stimulated with PMA and ionomycin. Ninety genes were up-regulated and 256 genes were down-regulated. b Scatterplot representation of correlation between cells expressing the BCOR K607E mutant and transfected BCOR siRNA. c Molecular functions, biological processes, and cellular components that were upregulated in the BCOR K607E mutant expressing cells as compared to cells expressing the wild-type BCOR, determined via GO analysis of genes